How does insulin lowers T ?

[chipdouglas]

Below is a quote from the other board, where Marianco posted. We all know that low T decreases insulin sensitivity, but how does high serum insulin decreases T *exactly* ? What's the mechanism at work ?



**Insulin:
1. Excess insulin can reduce testosterone production.
2. Has pro-inflammatory signaling functions.
3. etc. etc. etc.**

[hardasnails1973]

cortisol goes up insulin goes up. Cortisol goes up dhea levels go up then cortisol remains up dhea drops. Progesterione is shunted towards cortisol pathways vs testoserone. Basically your building block T is gone !!

[chipdouglas]

cortisol goes up insulin goes up. Cortisol goes up dhea levels go up then cortisol remains up dhea drops. Progesterione is shunted towards cortisol pathways vs testoserone. Basically your building block T is gone !!

Thanks HAN that was very clear and to the point....excellent.

[wondering]

HAN The effect of Cortisol on DHEA is where i think im headed. Currently have the high DHEA and low cortisol .. hoping helpig increase cortisol will help blanace out the DHEA.


cortisol goes up insulin goes up. Cortisol goes up dhea levels go up then cortisol remains up dhea drops. Progesterione is shunted towards cortisol pathways vs testoserone. Basically your building block T is gone !!

[hardasnails1973]

Was this verified by salvia test or blood test? I have same problem. If you have high tissues dhea then you have problems in detoxifiying it and it could be cloggin up receptors. This happens in undermethyation of the liver..

[wondering]

The theory of upping Cortisol balancing out DHEA has not, yet.

But yes BW shows lowish 8AM Cortisol and multiple Blood tests and Urine show high end DHEA.



Was this verified by salvia test or blood test? I have same problem. If you have high tissues dhea then you have problems in detoxifiying it and it could be cloggin up receptors. This happens in undermethyation of the liver..

[wondering]

apologies to Chip.

Looks like you received the info from HAN you were looking for.. but I still hijacked your thread - just realized it. Sorry.



Thanks HAN that was very clear and to the point....excellent.

[chipdouglas]

apologies to Chip.

Looks like you received the info from HAN you were looking for.. but I still hijacked your thread - just realized it. Sorry.

Don't sweat it dude, it's no biggie :)

[hardasnails1973]

The theory of upping Cortisol balancing out DHEA has not, yet.

But yes BW shows lowish 8AM Cortisol and multiple Blood tests and Urine show high end DHEA.

Need to bleed out the DHEA or to counter balance with cortisol ..

[wondering]

I'm inclined to believe Cortisol is my answer, but what do you mean by "bleed out".. literally go to red cross and donate blood?


Need to bleed out the DHEA or to counter balance with cortisol ..

[hardasnails1973]

detoxify the DHEA from receptors from blocking the cortisol

[wondering]

sorry.. but still not sure what you mean... how is this done?


detoxify the DHEA from receptors from blocking the cortisol

[Dr. John Crisler]

From a lecture I give on behalf of Androgel:

Insulin receptors are located on the Leydig cells and during insulin resistant states the production of testosterone by these cells is impaired, leading to further decreases in total testosterone.

[hardasnails1973]

From a lecture I give on behalf of Androgel:

Insulin receptors are located on the Leydig cells and during insulin resistant states the production of testosterone by these cells is impaired, leading to further decreases in total testosterone.

So in theory or fact cortisol and estrogen have the same affinity for testosterone receptors blocking testosterone production. This could also explain why mamgning 16 and 4 hydrox estrones is essential for proper hormone homostasis

[wondering]

k.. but 2 hr glucose test showed sensitivity to Insulin and Glucose test showed borderline Hypoglycemia.. not sure I am in Insulin resistant state.


From a lecture I give on behalf of Androgel:

Insulin receptors are located on the Leydig cells and during insulin resistant states the production of testosterone by these cells is impaired, leading to further decreases in total testosterone.

[wondering]

Sorry... realize now you were answering the question on original post.

Makes sense.. i gotta stop commenting in this thread... LOL.


From a lecture I give on behalf of Androgel:

Insulin receptors are located on the Leydig cells and during insulin resistant states the production of testosterone by these cells is impaired, leading to further decreases in total testosterone.

[hardasnails1973]

k.. but 2 hr glucose test showed sensitivity to Insulin and Glucose test showed borderline Hypoglycemia.. not sure I am in Insulin resistant state.

2 hour glucose test needs to have glucose and inuslin both done at same time other words it does not tell u insulin sensitibity or resistance. Or may be it does

[Dr. John Crisler]

So in theory or fact cortisol and estrogen have the same affinity for testosterone receptors blocking testosterone production. This could also explain why mamgning 16 and 4 hydrox estrones is essential for proper hormone homostasis

What evidence do we have of cortisol and estrogen binding to androgen receptors?

[Dr. John Crisler]

So in theory or fact cortisol and estrogen have the same affinity for testosterone receptors blocking testosterone production. This could also explain why mamgning 16 and 4 hydrox estrones is essential for proper hormone homostasis

I'm not sure why you are drawing the conclusion you have.

[hardasnails1973]

So the mechanism that causes testosterone to drop in relationship to elevated cortisol would be the diversion of progesterone to production of cortisol rather then it being used for testosterone. So cortisol does not block androgen receptors. is this scientifically correct? ia m just trying to understand this more clearly..Androgen recptors are new to me and I am just skimming the top of them. there is so much miss infomration out there

[pmgamer18]

Here is a good link.
http://jcem.endojournals.org/cgi/content/full/85/9/3024

So the mechanism that causes testosterone to drop in relationship to elevated cortisol would be the diversion of progesterone to production of cortisol rather then it being used for testosterone. So cortisol does not block androgen receptors. is this scientifically correct? ia m just trying to understand this more clearly..Androgen recptors are new to me and I am just skimming the top of them. there is so much miss infomration out there

[chipdouglas]

From a lecture I give on behalf of Androgel:

Insulin receptors are located on the Leydig cells and during insulin resistant states the production of testosterone by these cells is impaired, leading to further decreases in total testosterone.

Ah ah ! Thanks Dr. John---this is pretty much what I was looking for.