Could Dim possiible increase e2

[hardasnails1973]

If all other variables where consitant in TRT and the ratio of 2/16 was out of balance and this resulted in decrease of FT then could it be possible by shfiting the ratio to more benefical that this would increase FT (which my blood test have indicated it doubled) as well did the e2 from 28 to 57

So it may be posible that for some DIm actually increases e2 thorugh increassing FT / bio levels?

[Jaydee]

I have noticed that most times I take DIM, I get symptoms of high E which I found odd. I cant back it up with blood tests, but I definately feel as though E rises when I take it.

I thought maybe this is due to the DIM promoting the liver to detoxify the E and it temporarily becoming more abundant in your body. In the same way your liver detoxifies anything - it gets worse before it gets better when its pulled out of the liver and is temporarily floating around in your bloodstream before it is excreted.

[hardasnails1973]

I am also finding out that iodoral and may be possible DIM may be increasing TBG (increases in estrogen production and binding thyroid hormones)l due to the increase of estrogens. I don't think the liver can disquish between bad or good. It just identifies it as an estrogen and produces shbg. Just a thought

Increased levels of TBG lead to lowered free T4 concentrations (which may explain my all of sudden low t4 levels on test from iodoral), which results in elevated TSH secretion by the pituitary and (which also occured from .5 to 2.5) , consequently, enhanced production and secretion of thyroid hormones. The net effect of elevated TBG synthesis is to force a new equilibrium between free and bound thyroid hormones and thus a significant increase in total T4 and T3 levels.

[RugbyHooligan]

I've wondered about DIM myself a few times after taking it and it having the opposite effect as I expected it to have...

[Joejoebaggins]

How different are the effects of Iodine (Iodoral) and DIM? Don't they have similar action?

[hardasnails1973]

Dim shunts the pathways from 2 hydroxy to the 16,4 hydroxy and iodoral drains 16 hydroxy by changing it to estriol

[chipdouglas]

I haven't taken DIM to this day, but I3C, and found it to have an opposite effect as that expected. Libido goes way down, but erection improve for a few hours after ingestion though.

[Joejoebaggins]

HAN - Thanks for clearing that up for me. Some of this is actually starting to make sense since you posted the sticky of the pathways.

Was everyone taking TMG while on DIM? Isn't TMG critical?

[hardasnails1973]

I use Sam-e combined with TMG, but depends on person profile
normally any one with high histamine responds great to sam-e since its main detoxifcaiton of these as well as other estrogens. Histamines drive estrogen and can also be vice versa since they use the same pathway. Majiority of weight trainers are undermethyated because of depleeted gluthione levels and stress placed on antioxident reserves.

[Wise Guy]

If all other variables where consitant in TRT and the ratio of 2/16 was out of balance and this resulted in decrease of FT then could it be possible by shfiting the ratio to more benefical that this would increase FT (which my blood test have indicated it doubled) as well did the e2 from 28 to 57

So it may be posible that for some DIm actually increases e2 thorugh increassing FT / bio levels?

I don't really think DIM is going to increase FT/TT all that much.

Maybe clearing out 16/4 alpha hydroxy estrones would free up T receptors.

Those alpha estrones are a thousand times more potent than estradiol

Still, i don't see it increasing it so much that E2 suddenly goes threw the roof.

[hardasnails1973]

Dim free's up T receptors by removing the 16,4 a hydroxy-esterones which could explain the increase in free T. The increase of e2 I bet was from running out of pregenonlone creame 2 weeks before blood was drawn. Prrior before this test my e2 was 28 with same exact protocol with added pregnelone. I have an idea people with low cholesterol,on hcg and e2 problems have to take pregenolone to protect them from estrogenic effects