Shaking HCG Powder

[Bulldog]

I know you are not supposed to shake HCG once it is reconstituted because you can easily damage it. But what about the raw powder? I received a shipment from ANEWrx and usually the powder is packed to the bottom of the vials. However, this shipment the powder was all over in the vials from being shaken during shipment. Can this damage the HCG?

[spiderRico]

I wonder the same thing. Whenever I get my HCG from them the powder is all broken up instead of solid at the bottom.

Has me a liitle worried.

[cpeil2]

I think the business about hCG being such a fragile molecule that it can be denatured just by agitating the solution has been debunked as message board lore. Dr. John pointed out that there is a great amount of turbulence involved in drawing the reconstituted hormone up into the syringe. I believe Chilln deliberately shakes his because he believes the hormone forms a layer in the diluent and he wants to make sure it is evenly distributed throughout same before he draws up a dose. Ergo, if it is not that fragile in solution, I don't think that the powder would be any more fragile.

[pmgamer18]

When I buy something that needs to be put together I read how to do this. In my HCG insert is states to not shake it after you mix it. I feel when you do this it builds up pressure in the vial and you can break the seal.

My HCG powder looks like this at times and it's not a problem after mixing. And before I add in the Bac. water I pull out the amount of water I am going to put into the vial in air so when I add the water I don't blow the seal in the vial this did happen to me.

I think the business about hCG being such a fragile molecule that it can be denatured just by agitating the solution has been debunked as message board lore. Dr. John pointed out that there is a great amount of turbulence involved in drawing the reconstituted hormone up into the syringe. I believe Chilln deliberately shakes his because he believes the hormone forms a layer in the diluent and he wants to make sure it is evenly distributed throughout same before he draws up a dose. Ergo, if it is not that fragile in solution, I don't think that the powder would be any more fragile.

[JanSz]

I think the business about hCG being such a fragile molecule that it can be denatured just by agitating the solution has been debunked as message board lore. Dr. John pointed out that there is a great amount of turbulence involved in drawing the reconstituted hormone up into the syringe. I believe Chilln deliberately shakes his because he believes the hormone forms a layer in the diluent and he wants to make sure it is evenly distributed throughout same before he draws up a dose. Ergo, if it is not that fragile in solution, I don't think that the powder would be any more fragile.

Chilln use Ovidrel, possibly it is ok to shake it.

I use a HUCOG often.

When mixing I roll it rather gently otherwise it foams.
It takes days for the bubbles to settle.

When there are bubbles inside the vial they like to stick to and stay within rubber seal, regardless of vial position.

I do not worry about turbulences destroying the mixture, just the physics of getting the solution into syringe.
I am not able to draw liquid into syringe, as long as there are bubbles.
Worst is to take out last portion.

When bubbles make into syringes, they will not float up.
I do not want to inject air.

//

[Dadnatron]

I do not worry about turbulences destroying the mixture, just the physics of getting the solution into syringe.
I am not able to draw liquid into syringe, as long as there are bubbles.

When bubbles make into syringes, they will not float up.
I do not want to inject air.

//

While injecting 'air' is not optimal, unless you are in an artery, there is no real harm. Even injecting air into a vein isn't significantly harmful, unless there is a significant amount or you have a right to left cardiac shunt. Otherwise, the air 'bubble' will simply be filtered out by the lungs where it will be resorbed into the lung tissue quite quickly.

I have seen 40CC of air injected into a vein (on accident) when I was in training. We could see the air in the lungs... the patient got a little short of breath for about 1 minute, then the air was gone and the patient completely normalized. As long as it goes through the lungs, you are good to go.

For most people, injecting SQ, you are NOT going to be in a vein and are NO WHERE CLOSE to an artery. I inject lidocaine into patients several times a day, and on some postop studies, I see air injected in the mix. It sits there in the tissue until it is resorbed.

Stay out of an artery and you don't have to worry about injecting air.

[cpeil2]

Chilln use Ovidrel, possibly it is ok to shake it.

I use a HUCOG often.

When mixing I roll it rather gently otherwise it foams.
It takes days for the bubbles to settle.

When there are bubbles inside the vial they like to stick to and stay within rubber seal, regardless of vial position.

I do not worry about turbulences destroying the mixture, just the physics of getting the solution into syringe.
I am not able to draw liquid into syringe, as long as there are bubbles.
Worst is to take out last portion.

When bubbles make into syringes, they will not float up.
I do not want to inject air.

//

Bubbles?

I have been using 5000IU vials of compounded hormone because it costs so much less than the branded hormone. I don't notice any difference in effect. With the branded hormone, I would occasionally experience the hCG glow, but mostly not. The experience is the same w/ the compounded. They both plump my testes equally well. The compounded hormone does foam a little bit more when reconstituting, but the bubbles settle out readily.