Bad Reaction - Anastrozole

[Hemochromatosis]

I realize most will not beleive this, maybe it is the hemochromatosis or some other predisposition causing a compliation, but from 2 doses of anastrozole .25 mg's 72 hours apart and I am still have a severe reaction and may be heading to the hospital or ER soon since I have been up the last two nights and it is getting progressively worse.

Took the first .25 on 3/5 morning and second on 3/8 morning and have been messed up since

Dry mouth, shakes, elevated bp, high pulse, not a head ache but throbbing paint to the back of the head, chills, sweats the classic adverse reactions.

I cant seem to elevate my body temp above 97 with most of the time I am in the 96's. It apears the first 30 minutes of wake everything elevates then soemwhat normalizes.

my glucose seemed to be ok until I ate a small bowl of instant oatmeal, splenda and cinnamon, gluc spiked to 140 where it has been maintained during first AM/fast periods at around 105 give or take

afib is more erratic than in years, right side weak, nauseated big time

my T inject was on 3/10 wednesday AM, talked to my primary who said stop the anastrolzole and I agreed to down dose T cyp inject from .5ml (100mg) to .25ml (50 mgs) seeking to lower my TT from and average of 675-700 to 475-500 pg/ml with the ultimate objective of lowering the E2 which at last test was at 50 pg/ml......

I really do not want to go into the ER, AGAIN, but with all of my issues I am concerned about falling out and having another event, stroke, etc

ANY THOUGHTS ARE APPRECIATED

[GirlyMan]

ANY THOUGHTS ARE APPRECIATED

Damn, Hemo. Only thought I have is I hope it resolves quickly.

I really hope I never have to start mucking with E2. Scares the shit out of me for some reason.

[Lucky1]

I realize most will not beleive this, maybe it is the hemochromatosis or some other predisposition causing a compliation, but from 2 doses of anastrozole .25 mg's 72 hours apart and I am still have a severe reaction and may be heading to the hospital or ER soon since I have been up the last two nights and it is getting progressively worse.

Took the first .25 on 3/5 morning and second on 3/8 morning and have been messed up since

Dry mouth, shakes, elevated bp, high pulse, not a head ache but throbbing paint to the back of the head, chills, sweats the classic adverse reactions.

I cant seem to elevate my body temp above 97 with most of the time I am in the 96's. It apears the first 30 minutes of wake everything elevates then soemwhat normalizes.

my glucose seemed to be ok until I ate a small bowl of instant oatmeal, splenda and cinnamon, gluc spiked to 140 where it has been maintained during first AM/fast periods at around 105 give or take

afib is more erratic than in years, right side weak, nauseated big time

my T inject was on 3/10 wednesday AM, talked to my primary who said stop the anastrolzole and I agreed to down dose T cyp inject from .5ml (100mg) to .25ml (50 mgs) seeking to lower my TT from and average of 675-700 to 475-500 pg/ml with the ultimate objective of lowering the E2 which at last test was at 50 pg/ml......

I really do not want to go into the ER, AGAIN, but with all of my issues I am concerned about falling out and having another event, stroke, etc

ANY THOUGHTS ARE APPRECIATED

I hope every thing works out for you!! I'm kind of in the same boat as you. I'm 46, type 2, and have high E2's, and High DHT, The difference is my doctor, does not want to put me on an AI. I hope you get better soon!!

[Hemochromatosis]

Damn, Hemo. Only thought I have is I hope it resolves quickly.

I really hope I never have to start mucking with E2. Scares the shit out of me for some reason.

It is hammering me bad, i dont get it everyone in here seems to have no problem with it.........my TT was originally 140 and if elevating to 475-500 keeps AM wood and all else works and lowers E2........but what has crossed my mind is that even though i have the classic adverse reactions, I ma sure the 2 doses ahd some effect on E2 level, that combined with a T inject down dose my E2 may be swinging hard down, which I do not know the implications of......

This sucks and the WBM at least in the extract I obtained had too much purine and uric acid spiking to tell if it could serve as an AI........i still think WBM has promise but there needs to be an extractor that can filter out the purines and isolate the phytocons.........

the wierd part about this reactions is that my vitals as i track, are amped up when i first get up or rise from sleep, which was 4 times last night......and the night before.....and then they start to come down........the shakes and chills come random and the pulsing head pain, which is not like anything i have ever felt presented last night.......

isnt there a half life to this stuff.......i cant beleive the micro doses are bouncing me so damn hard....i just hope it does not progress to anything else.....i cant find anything .........

just off the phone with primary doctor, she tends to think it is not the T or anastrozole driving the train, but more a renal issue or adrenal.........I am on adrenal rebuilder.......never had an issue before.....

[Hemochromatosis]

I hope every thing works out for you!! I'm kind of in the same boat as you. I'm 46, type 2, and have high E2's, and High DHT, The difference is my doctor, does not want to put me on an AI. I hope you get better soon!!

thanks......the problem with me is with atril fibrillation, the E2 at over 30 pg/ml increases stroke by a factor of 2.2, i was last at 50 pg/ml......once was enough......i tend to agree with my doc that it is not all attributed to 2 micro doses of anastrozole but more related to adrenal/renal......

[Lucky1]

thanks......the problem with me is with atril fibrillation, the E2 at over 30 pg/ml increases stroke by a factor of 2.2, i was last at 50 pg/ml......once was enough......i tend to agree with my doc that it is not all attributed to 2 micro doses of anastrozole but more related to adrenal/renal......

It's funny you mentioned that. When I was 25, I was getting a BJ, and all of the sudden, it felt like my heart stopped. I had my wife take me to the hospital. It turns out that was the start of my heart palpitations. After that, I had bad anxiety, for the next year. They put me on Tenormin, to stop the palpation's. Year's later its a normal part of my life.

About three year ago, I started with accelerated pulse, around 110 ppm. My cardiologist put me on Atenolol, to slow down my heart, but never check why it was going so fast. Last my my primary doctor, to me off that an put me on Bystolic. I'm not sure what is causing my fast pulse....

[Hemochromatosis]

It's funny you mentioned that. When I was 25, I was getting a BJ, and all of the sudden, it felt like my heart stopped. I had my wife take me to the hospital. It turns out that was the start of my heart palpitations. After that, I had bad anxiety, for the next year. They put me on Tenormin, to stop the palpation's. Year's later its a normal part of my life.

About three year ago, I started with accelerated pulse, around 110 ppm. My cardiologist put me on Atenolol, to slow down my heart, but never check why it was going so fast. Last my my primary doctor, to me off that an put me on Bystolic. I'm not sure what is causing my fast pulse....

if no one thins you a chance of stroke is significantly more probable

[cumkwakka]

i had this bad reaction as well on low dose .25 mg it's why i inquired for other aromatase inhibitors

any ideas? more ppl seem to be having this issue

[Hemochromatosis]

i had this bad reaction as well on low dose .25 mg it's why i inquired for other aromatase inhibitors

any ideas? more ppl seem to be having this issue

cumkwakka: need more data, your stats, diagnosis/conditions, circumstance of reaction, details.........

[chilln]

I realize most will not beleive this, maybe it is the hemochromatosis or some other predisposition causing a compliation, but from 2 doses of anastrozole .25 mg's 72 hours apart and I am still have a severe reaction and may be heading to the hospital or ER soon since I have been up the last two nights and it is getting progressively worse.

Took the first .25 on 3/5 morning and second on 3/8 morning and have been messed up since

Dry mouth, shakes, elevated bp, high pulse, not a head ache but throbbing paint to the back of the head, chills, sweats the classic adverse reactions.

I cant seem to elevate my body temp above 97 with most of the time I am in the 96's. It apears the first 30 minutes of wake everything elevates then soemwhat normalizes.

my glucose seemed to be ok until I ate a small bowl of instant oatmeal, splenda and cinnamon, gluc spiked to 140 where it has been maintained during first AM/fast periods at around 105 give or take

afib is more erratic than in years, right side weak, nauseated big time

my T inject was on 3/10 wednesday AM, talked to my primary who said stop the anastrolzole and I agreed to down dose T cyp inject from .5ml (100mg) to .25ml (50 mgs) seeking to lower my TT from and average of 675-700 to 475-500 pg/ml with the ultimate objective of lowering the E2 which at last test was at 50 pg/ml......

I really do not want to go into the ER, AGAIN, but with all of my issues I am concerned about falling out and having another event, stroke, etc

ANY THOUGHTS ARE APPRECIATED


When E2 goes too low, our bodies suffer - ie: biochemical processes do not complete and leave free radicals hanging around which interfere with other normal processes unrelated to E2 metabolism.

Then the body sends out cortisol to combat the cascading free radical damage.

If your cortisol is already too low (ie: if your adrenals can't pump more cortisol on demand) then you'll suffer the effects you're feeling now.

You need to boost your cortisol.

Those adrenal boosters can't deliver a "stress dose" which makes them dangerous.

How to boost cortisol is discussed here:

http://musclechatroom.com/forum/showpost.php?p=80342&postcount=316

.

[chilln]

i had this bad reaction as well on low dose .25 mg it's why i inquired for other aromatase inhibitors

any ideas? more ppl seem to be having this issue

When E2 goes too low, our bodies suffer - ie: biochemical processes do not complete and leave free radicals hanging around which interfere with other normal processes unrelated to E2 metabolism.

Then the body sends out cortisol to combat the cascading free radical damage.

Cortisol reduces the micro-inflammation which is a normal response to free radical damage.

If your cortisol is already too low (ie: if your adrenals can't pump more cortisol on demand) then you'll suffer the effects you're feeling now.

How to boost cortisol is discussed here:

http://musclechatroom.com/forum/showpost.php?p=80342&postcount=316

.

[blackhawks]

Arimidex made me feel absolutely terrible... I was taking a 1/4 of a 1mg tab every other day. Cough/cold....sneezing, couldnt sleep at all, sores on my legs, couldnt relax.... many more things. after one month i stopped cuz i couldnt take it any more. my E2 went from 29 to non existant. They couldnt even measure it. My test dropped from 505 to 325.

Im guessing that some people just cant take the stuff. So now im waiting for my next blood test results. Im just hoping there is a way to manage my E2.
E2 sucks!

[chilln]

Arimidex made me feel absolutely terrible... I was taking a 1/4 of a 1mg tab every other day.


Obviously too much arimidex and therefore too little E2.

Your medical professional adviser should have prescribed for you arimidex as 0.05mg compounded caps, as discussed here:

http://musclechatroom.com/forum/showpost.php?p=59066&postcount=31

.

[pmgamer18]

Like Chilln says it looks to me like you all went to low. Some men can't take .25 mgs even every 5 days I was like this on a gels my levels were not high enough in T to keep my levels in the sweet spot just taking .25 mgs every 5 days. So I switched to Indolplex/DIM ended up only doing one half a tablet a day.

I went about 5 yrs on gels with my levels to low it was when I switched to shots my levels came up then I added in HCG. Now DIM would not keep my e2 levels down so I went back on arimidex. Most of the time I do great taking .25 mgs every 3 days. Here is a copy of a file I made on how I keep from going to low on Arimidex.
=====================================
What I found is if you go to low taking arimidex, it's the length of time your to low, if your too low say for 8 weeks it can take your body a longer time to make more Estradiol. Bottom line is to know how not to go to low. Keep a log on your dose and how you feel men going to low can't get it up taking Viagra. I went to low when I first tried Arimidex and did not know about going to low or how one feels to low, so I was low a good 8 weeks. I did not know I was low until my next labs.

The best gage I have found to control your Estradiol levels is to gage your night time and morning wood. At good levels or what I call the sweet spot you get your night time and morning wood back so strong it will wake you up and you can hang a coat on it.

Most men do good taking .25 mgs or 1/4 of a 1mg. pill, I use a pill cutter to cut the small pill in half then I stand it on the cut end and use a single edge razor to cut this in half. A good way to take arimidex is by how high your levels are. I tested over 90 pg/ml so we tried doing .5 mgs every other day after 8 weeks my next set of labs showed it did not move below 90, test said >90. So we did .5 mgs. every day in about 2 weeks I got some strong night time and morning wood back after not having them for many yrs.

I kept doing this dose and in 8 weeks my next set of labs said <20 back in the day labs were like this they did not have to good labs we have today they could not read lower the 20. My Dr. told me this looks to low to stop taking the Arimidex. The one thing I noticed was my wood stopped and stopping the Arimidex my wood came back in about 7 weeks my next test at 8 weeks was 24 pg/ml. So we went back on the Arimidex but the Dr. told me to take .5 mgs every 3 days I was on this dose not a week and lost wood. This is when I figured out going to low you lose wood. And the longer your too low the longer it takes to get levels back up.

I stopped the arimidex right away and got my wood back in 4 days. I then after playing with the dose for a time found the best dose is .25mgs every 2 to 3 days.

So lets say your labs are less the 50 pg/ml if your take .5 mgs you can go down so dam fast your miss the sweet spot of your wood and go to low. It's best with lower levels 50 and under to do less Arimidex .25mgs every 2 days if later your lose wood when it comes back go to every 3 days.

I have found estradiol is the hardest hormone to control, it goes up or down from month to month some times I need .25mgs every 2 days other times I need .25mgs everyday most of the time I do well on every 3 days.

So between wood and labs I do great and so do most of the men I have told this to. I keep a log on how much I am taking and how I feel. Doing this and reading back in my log I was able to tell when I was going to high or to low my Dr. lets me dose my arimidex by how I feel.

Over the yrs. I have posted this story until I am blue in the face.


=====================================
The following is a copy of a post by Chilln
=====================================
Most compounding pharmacies will require a prescription from a doctor, before they do this.

Once your prescription says "300 caps x 0.1mg" or "600 caps x 0.05mg" anastrozole "from 1 to 4 daily", (anastrozole = generic arimidex) then they will compound your arimidex, or generic anastrozole, and they will usually supply the arimidex as compounded into the caps you require.

My compounding pharmacist was prepared to allow me to supply the arimidex too. If you have several boxes of arimidex in your cupboard, then you may want to ask your pharmacist to do this for you.

If you don't have any arimidex stores, then just let the compounding pharmacy supply the whole lot.

###

A pack of 30 tabs of 1.0mg arimidex will give 300 caps at 0.1mg-per-cap, or 600 caps at 0.05mg-per-cap.

So if your pharmacy chooses to supply arimidex as opposed to generic anastrozole, then your pharmacy will most likely not agree to only charge you for a half-a-box of arimidex, and most likely they'll charge for a whole box, even if your prescription says 300 caps at 0.05mg-per-cap (total of 15mg).

[Hemochromatosis]

When E2 goes too low, our bodies suffer - ie: biochemical processes do not complete and leave free radicals hanging around which interfere with other normal processes unrelated to E2 metabolism.

Then the body sends out cortisol to combat the cascading free radical damage.

If your cortisol is already too low (ie: if your adrenals can't pump more cortisol on demand) then you'll suffer the effects you're feeling now.

You need to boost your cortisol.

Those adrenal boosters can't deliver a "stress dose" which makes them dangerous.

How to boost cortisol is discussed here:

http://musclechatroom.com/forum/showpost.php?p=80342&postcount=316

.

you are on the money mister, i just went through a train wreck of testing including a mri with contrast to rule out tumor formation or a leaky brain.....this was a big confirm and while i need to address the issue more fully with labs i intuitively sense you are spot on....primary has been saying same thing....

[Hemochromatosis]

When E2 goes too low, our bodies suffer - ie: biochemical processes do not complete and leave free radicals hanging around which interfere with other normal processes unrelated to E2 metabolism.

Then the body sends out cortisol to combat the cascading free radical damage.

If your cortisol is already too low (ie: if your adrenals can't pump more cortisol on demand) then you'll suffer the effects you're feeling now.

You need to boost your cortisol.

Those adrenal boosters can't deliver a "stress dose" which makes them dangerous.

How to boost cortisol is discussed here:

http://musclechatroom.com/forum/showpost.php?p=80342&postcount=316

.


Well you were right in part I dropped my E2 from 50 to 28.2, not sure if that is enough of a dip to make everything go off.

Also, cortisol was 12.6 ug/dL (and I realize this is blood not saliva) and TT was 404 ng/dl (1/2 doses at .25ml (50mg) instead of .5ml/100mg)

My coumadin protime INR was very high at 4.1 and it was explained to me that the anastrozole will raise the coumadin level. Keeping in mind I only used (2) .25mg doses 72 hours apart.....

also I used a swish and spit mouthwash that had antibiotics which will jack up IRN level.........so

now i am off coumadin for two days.....if the headache does not stop then the only thing left is a capped molar that has decided to inflame.......

more labs later.........been bed ridden better part of 9 days time to get out.....

[Hemochromatosis]

Strange, since my E2 is starting to come down, even without being in the gym for 2 months, i almost feel like i am ripped, very odd! just like sea monkeys...add water! now if i can get rid of a 9 day headache!

[Dex09]

I have experienced similar symptoms from adex but only if above .5mg a week .. start feeling fatigued like before cortef, all dried up eyes, face skin everything, then the headaches come exact same thing as you described.. only hours and hours of sleep days n nights on end seems to get rid of these headaches ... Before adex on hcg and test cyp, E2 was 50ish. Started adex .25 3 times aweek dropped to 22 didnt feel to good at all .. got worse over time .. so i do .25mg adex every 4-5days and all is good , morning wood, the higher dose adex symptoms gone .. funny thing is e2 is usually 35 or above but feel best this way.

[Hemochromatosis]

I have experienced similar symptoms from adex but only if above .5mg a week .. start feeling fatigued like before cortef, all dried up eyes, face skin everything, then the headaches come exact same thing as you described.. only hours and hours of sleep days n nights on end seems to get rid of these headaches ... Before adex on hcg and test cyp, E2 was 50ish. Started adex .25 3 times aweek dropped to 22 didnt feel to good at all .. got worse over time .. so i do .25mg adex every 4-5days and all is good , morning wood, the higher dose adex symptoms gone .. funny thing is e2 is usually 35 or above but feel best this way.

They, the proverbial, say that E2 over 30 increases stroke rate by 2.2 times...

There has to be a better way. I want to roll back on the clinical for WBM and contact them regarding the extraction. Especially with weight training and lifting guys in here their uric acid from eating so much protein must be high. This is why the wbm phytocons need to be isolated.......be interesting to see who they used or if they extracted themselves.......more on the other thread.......thanks for your input.....

[Hemochromatosis]

I have experienced similar symptoms from adex but only if above .5mg a week .. start feeling fatigued like before cortef, all dried up eyes, face skin everything, then the headaches come exact same thing as you described.. only hours and hours of sleep days n nights on end seems to get rid of these headaches ... Before adex on hcg and test cyp, E2 was 50ish. Started adex .25 3 times aweek dropped to 22 didnt feel to good at all .. got worse over time .. so i do .25mg adex every 4-5days and all is good , morning wood, the higher dose adex symptoms gone .. funny thing is e2 is usually 35 or above but feel best this way.

how long did it take these killer headaches to subside? I am at 2 weeks and constant broken sleep it is messing me up.

[chilln]

Strange, since my E2 is starting to come down, even without being in the gym for 2 months, i almost feel like i am ripped, very odd!


Nothing odd about optimum E2. Feels great.

Hormone optimization really shows awesome benefits, provided you acquire the knowledge which complements your medical professional adviser's knowledge, so that together you make a fearsome team.

.

[Hemochromatosis]

Nothing odd about optimum E2. Feels great.

Hormone optimization really shows awesome benefits, provided you acquire the knowledge which complements your medical professional adviser's knowledge, so that together you make a fearsome team.
.

There is much to know and I agree you need to be an active participant as part of a team. Dr. Crisler has a fine group in here and you are a definite asset. Thank you for taking the time to reply. With as much ignorance and big pharm and regulated practice conventional doctors exhibit, it is very clear that Dr. Crisler holds a unique place in getting down to it.

Sidenote: More and more I suspect this headache was not caused by anastrozole, but a tooth in need of a root canal.

[Hemochromatosis]

still getting headaches..........getting root canal tomorrow...........if i eliminate the tooth possibility the pain and throbbing in my head, which has been for 2 weeks now and have woke me every night since has to be the anastrozole or the reduction of E2

[JanSz]

still getting headaches..........getting root canal tomorrow...........if i eliminate the tooth possibility the pain and throbbing in my head, which has been for 2 weeks now and have woke me every night since has to be the anastrozole or the reduction of E2

root canal
stress
antibiotics

think of any adrenal support
think of enzymes, probiotics

................

[Hemochromatosis]

root canal
stress
antibiotics

think of any adrenal support
think of enzymes, probiotics

................

i am bring my T dose back up incrementallu to where i was if my E2 elevates o well I wont go back ot 675 i will go to 500 but TT dropped to 405.........I am worthless like this can not funciton, even typing is a biotch

appears that it is not a root canal, peridontal inflmation yes, etc.....

assuming this is from the anastrozole how long is it going to take to stop

i maybe had a half dozen headaches in a lifetime, other than hangover related when i was young

[Hemochromatosis]

root canal
stress
antibiotics

think of any adrenal support
think of enzymes, probiotics

................

Root canal was not necessary and it was determined my head pulses and head pains not ache, which started just after the second dose of anastrozole is not tooth related ($1400 later).

There have been a few other posts in reply that share similar experiences.

My reaction to the drug was text book. However, I can find nothing regarding the treatment of an adverse reaction to arimidex/anastrozole or anything that gives insight as to how long these headpains will last......

[Hemochromatosis]

There has been people who have posted in here and I can find examples on the net to others who have had similar adverse reactions to anastrozole/arimidex.

What I can not find is if there are any treatments to the adverse reaction or any logging of how long it takes a now 16 day headache/pain/pulse to go away?

IS THERE ANY KNOWLEDGE REGARDING ADVERSE REACTIONS AND WHAT CAN BE DONE?

[Dex09]

Sorry to hear your still getting these dreadful headaches .. i know how they feel with just normal dosing adex .25 3-4x a week ... i found that extra sleep, sleep as much as poss(thats all I felt like doing anyways) that you can and also i increased my HCG dose from usual 250iu a week to as much as 500iu 3x a week and also increased dhea from 25-50mg micronised to help get back the e2 that adex lowered(Increased for 1 week only then back to normal dose).

As said in the messagejust sent usually they lasted 2 days for me but before increasing the hcg+dhea they would last as long as a week where your body jsut cant function at all :

Dry, drained, weak, heavy heavy throbbing headaches, sore joints, back, feel like death basically etc

[Hemochromatosis]

Sorry to hear your still getting these dreadful headaches .. i know how they feel with just normal dosing adex .25 3-4x a week ... i found that extra sleep, sleep as much as poss(thats all I felt like doing anyways) that you can and also i increased my HCG dose from usual 250iu a week to as much as 500iu 3x a week and also increased dhea from 25-50mg micronised to help get back the e2 that adex lowered(Increased for 1 week only then back to normal dose).

As said in the messagejust sent usually they lasted 2 days for me but before increasing the hcg+dhea they would last as long as a week where your body jsut cant function at all :

Dry, drained, weak, heavy heavy throbbing headaches, sore joints, back, feel like death basically etc

thanks.........i have had to stop the Tylenol, only thing i can take to mask it for a few hours.......i am going to have to find a local endocrinologist in the interim....i am quickly going broke over health care so i am forced to go find someone of convention to tell me how my TT at 675 is too high and how I only need to shoot T once every 3 weeks.......discouraging

[Hemochromatosis]

most concerned about a perpetual cascade that is just going to continue to devastate and get worse or is there a path back?

[GirlyMan]

most concerned about a perpetual cascade that is just going to continue to devastate and get worse or is there a path back?

paths worth following go many directions, cul-de-sacs lead to the abyss. Nice place to visit but I wouldn't want to live there.

[Hemochromatosis]

paths worth following go many directions, cul-de-sacs lead to the abyss. Nice place to visit but I wouldn't want to live there.

My decoder ring is at the bottom of my captain crunch.......have you been OD'ing on Chinese fortune cookies?

[GirlyMan]

....have you been OD'ing on Chinese fortune cookies?

Uh ... maybe ... but only the low-carb ones. I gotta keep an eye on my sugars.

[chemman]

Arimidex made me feel absolutely terrible... I was taking a 1/4 of a 1mg tab every other day. Cough/cold....sneezing, couldnt sleep at all, sores on my legs, couldnt relax.... many more things. after one month i stopped cuz i couldnt take it any more. my E2 went from 29 to non existant. They couldnt even measure it. My test dropped from 505 to 325.

Im guessing that some people just cant take the stuff. So now im waiting for my next blood test results. Im just hoping there is a way to manage my E2.
E2 sucks!

I know that this is an old thread, but T dropped as a result of lowering E2? Now THAT is interesting.

[spiderRico]

I'm having this problem with Anastrozole also. It feels like I'm driving my estrogen too low, and it coincides with low cortisol. Because it's only in the morning. It makes me feel deathly ill. Burning eyes, extreme pressure in my head.

I think it has something to do with my liver. I have taken it in the past with absolutely no problems. I was taking up to 1 mg a day trying restarts with no problems. And now I can't handle .5 mg eod.

It all changed when I went on multiple antibiotics for Lyme. Now a few of my liver enzymes are elevated. I believe this has to be the reason.

[random321]

Despite the reputation Arimdex has for having 'no side effects,' it's actually quite a nasty drug known to cause lots of side effects. I'd avoid it if at all possible. If you only need to lower your e2 10-30 points, you can probably easily do that with Zinc and/or calcium D-glucarate. DIM if necessary.

[chemman]

Despite the reputation Arimdex has for having 'no side effects,' it's actually quite a nasty drug known to cause lots of side effects. I'd avoid it if at all possible. If you only need to lower your e2 10-30 points, you can probably easily do that with Zinc and/or calcium D-glucarate. DIM if necessary.

Arimidex is some nasty ****. I tried using a low dose of adex about a year ago and it screwed me up royally. Now, on TRT with peak TT at 950 and SHBG of 20, my E2 is 18, which is probably too low for me. I still have low E2 symptoms like cracking joints 1 year after low-dose adex.

Does anybody know if adex can cause permanent/long-lasting effects on the Estradiol pathways similar to finasteride and 5-AR?

[chilln]

Arimidex is some nasty ****. I tried using a low dose of adex about a year ago and it screwed me up royally. Now, on TRT with peak TT at 950 and SHBG of 20, my E2 is 18, which is probably too low for me. I still have low E2 symptoms like cracking joints 1 year after low-dose adex.

Does anybody know if adex can cause permanent/long-lasting effects on the Estradiol pathways similar to finasteride and 5-AR?

Most likely your cortisol is too high.

When cortisol is high, it suppresses T metabolism, which reduces T conversion into DHT and E2.

Discuss monitoring your cortisol with your medical professional adviser, and see what you can do about lowering it.

.

[JanSz]

Arimidex is some nasty ****. I tried using a low dose of adex about a year ago and it screwed me up royally. Now, on TRT with peak TT at 950 and SHBG of 20, my E2 is 18, which is probably too low for me. I still have low E2 symptoms like cracking joints 1 year after low-dose adex.

Does anybody know if adex can cause permanent/long-lasting effects on the Estradiol pathways similar to finasteride and 5-AR?

More or less, regardless of SHBG level,
but definitely when one have his SHBG=20 (at a sweet spot)
good E2 values are in this range

Estradiol (10–30) pg/mL

http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=114133

Whatewer problems you have leave TT=950, SHBG=20, & E2=18 alone.
Do not thinker with them.

Your problem lies elsewhere.


...

[Picton]

Arimidex is some nasty ****. I tried using a low dose of adex about a year ago and it screwed me up royally. Now, on TRT with peak TT at 950 and SHBG of 20, my E2 is 18, which is probably too low for me. I still have low E2 symptoms like cracking joints 1 year after low-dose adex.

Does anybody know if adex can cause permanent/long-lasting effects on the Estradiol pathways similar to finasteride and 5-AR?

I had cracking joints 35 years ago before I had HEARD of E2 or Arimidex, I had cracking joints that would drown out JP Sousa's Band when I had astronomically high E2 and now I don't, guess what: I have cracking joints that still do a pretty good rendition of "Liberty Bell" on a daily basis, yet some days I don't crack at all, even my arthritic joints!

My arthritic joints often crack now... but oddly, those joints never cracked BEFORE I had arthritis!

I would suggest this cracking joints thing is a lot of tosh... cracking joints mean you have......... cracking joints!

I wish my Arimdex would last a whole year though!:cool:

I would suggest for me it has been the one drug that has had zero detectable side effects, unlike many others which have been spectacular in the extreme. Take Oral Terbinafine an anti fungal drug - very recently it has had me demented with severe insomnia, and electric shock-like episodes, worst in bed, but even durig the day too.... it all stopped within 48 hours of ceasing the drug - yet I can find NOTHING to suggest another single person has reported the same ill effect over the entire Internet. Unfortunately idiosyncratic responses are always possible -this time it was me that was the victim!

Finasteride is something with a profile defying belief, but I would suggest the wide use of Arimdex at far higher dosages than used by Bodybuilders and TRT treatment fails to produce anything like the same unpleasant profile, and I would hate anyone being dissuaded from using it and leaving E2 far too high with all of it's potential longer-term problems.

[chemman]

Most likely your cortisol is too high.

When cortisol is high, it suppresses T metabolism, which reduces T conversion into DHT and E2.

Discuss monitoring your cortisol with your medical professional adviser, and see what you can do about lowering it.

.

See: http://www.musclechatroom.com/forum/showpost.php?p=111530&postcount=50

Cortisol is monitored and present in [maybe?] sufficient quantity.