AE-3 as an Aromatase Inhibitor

[Hemochromatosis]

Just realized we are not suppose to post any links to products. I hope this remains compliant for I have no other interest other than usage and efficacy.

Has anyone tried AE-3 (Chrysin with Perine. Perine to potentiate and make bioavailable the Chrysin)

I tried Arimidex and on a low dose had a reaction. I looked into IC3, but am not convinced. My E2 is out of control and is at about a 10:1 to total T.

Please help.

[Wise Guy]

Just realized we are not suppose to post any links to products. I hope this remains compliant for I have no other interest other than usage and efficacy.

Has anyone tried AE-3 (Chrysin with Perine. Perine to potentiate and make bioavailable the Chrysin)

I tried Arimidex and on a low dose had a reaction. I looked into IC3, but am not convinced. My E2 is out of control and is at about a 10:1 to total T.

Please help.

From my understanding, and from what Dr John has posted numerous times, is that Chrysin products, even when compounded into a transdermal cream, are not strong enough as an aromatase inhibitor for pertinent use.

Others like Chrysin for its anti-anxiety properties and libido enhancing properties, but just know that its likely its not going to be enough.

Interestingly, I have seen some really, really convincing stuff about the use of calorie restriction as an effective aromatase inhibitor.

It seems to be the combination of calorie restriction genes being turned on, and the loss of body fat, which is its own aromatase producing organ.

[garcia]

Wise guy, is there no effective herbal aromatase inhibitor that you would recommend? I'm currently on Chrysin, but I don't think its strong enough.

[Wise Guy]

Wise guy, is there no effective herbal aromatase inhibitor that you would recommend? I'm currently on Chrysin, but I don't think its strong enough.

That would be cost effective? No.

The best bet would be to start some sort of calorie reduction diet. Cutting down on calories and trimming fat does wonders to turn on calorie restriction genes, which reduce estradiol levels.

When BF is shed, the fat that aromatizes into estrogen directly on sight, is reduced.

If that is not enough, one could look to reducing T dosage by boosting GH levels which will take over in repairing targeted tissues. The slightly reduced T levels will help bring estradiol down

If that is not enough, an AI is needed.

[garcia]

Thanks for the info Wise Guy.

If money were no object, what dosage/combination of herbs could you take to accomplish the same effect as an aromase inhibitor?

[Hemochromatosis]

From my understanding, and from what Dr John has posted numerous times, is that Chrysin products, even when compounded into a transdermal cream, are not strong enough as an aromatase inhibitor for pertinent use.

Others like Chrysin for its anti-anxiety properties and libido enhancing properties, but just know that its likely its not going to be enough.

Interestingly, I have seen some really, really convincing stuff about the use of calorie restriction as an effective aromatase inhibitor.

It seems to be the combination of calorie restriction genes being turned on, and the loss of body fat, which is its own aromatase producing organ.

WG please check this out http://ae-3.com/

This is not a transdermal cream, I would not consider anything topical after contending with testim. The emphasis is that the Bioperine makes the chrysin bioavailable and potentiates it. Bioperine has more than proven itself out on its boosting of other vitamins and minerals.

Also, regarding a caloric reduction: Unfortunately this forum is in a musclechat venue, which I can appreciate from a past life. Now, I come not as a pusher of irron, although I still have a cardio and resistance routine, but I now come from the other side of the coin having to contend with genetics and the disorders that come with it. I stress this because making reference to a caloric reduction program is, respectfully, assuming the individual has a metabolism that is capable. I usually maintain under 2000 calories a day and have those times I venture out into pizzaville. However, I have been involved with weight training and wrestling my entire life and get it. My case is different. I gained 30lbs when I went to T injections. Lost the 30 when I started an adrenal replenish program and have been at 270lbs for the better part of a year. My resistance training is a low weight/high rep routine with 30 minutes of elliptical to start. I drink purified water and monitor everything from protein to carbs to sugar, etc.

You touched on GH and as evidenced in another post I had in the welcome section I included a link to a Johns Hopkins clinical where people with my condition were based at 40lbs over, took T injects added 30 lbs more, started low doses (I believe 1 iu of HGH) and in 6 months, combined with a balanced and moderate diet and exercise approached, reduced waist inches and approached BMI.

I listed to Dr. J's recent radio interview and whatever was referenced to as a GH replenishment and not replacement caught my attention because it seems more logical and also the cost consideration when compared to HGH. What I did not understand was the reference to 10 lb weight gain.

[Wise Guy]

WG please check this out http://ae-3.com/

This is not a transdermal cream, I would not consider anything topical after contending with testim. The emphasis is that the Bioperine makes the chrysin bioavailable and potentiates it. Bioperine has more than proven itself out on its boosting of other vitamins and minerals.

Also, regarding a caloric reduction: Unfortunately this forum is in a musclechat venue, which I can appreciate from a past life. Now, I come not as a pusher of irron, although I still have a cardio and resistance routine, but I now come from the other side of the coin having to contend with genetics and the disorders that come with it. I stress this because making reference to a caloric reduction program is, respectfully, assuming the individual has a metabolism that is capable. I usually maintain under 2000 calories a day and have those times I venture out into pizzaville. However, I have been involved with weight training and wrestling my entire life and get it. My case is different. I gained 30lbs when I went to T injections. Lost the 30 when I started an adrenal replenish program and have been at 270lbs for the better part of a year. My resistance training is a low weight/high rep routine with 30 minutes of elliptical to start. I drink purified water and monitor everything from protein to carbs to sugar, etc.

You touched on GH and as evidenced in another post I had in the welcome section I included a link to a Johns Hopkins clinical where people with my condition were based at 40lbs over, took T injects added 30 lbs more, started low doses (I believe 1 iu of HGH) and in 6 months, combined with a balanced and moderate diet and exercise approached, reduced waist inches and approached BMI.

I listed to Dr. J's recent radio interview and whatever was referenced to as a GH replenishment and not replacement caught my attention because it seems more logical and also the cost consideration when compared to HGH. What I did not understand was the reference to 10 lb weight gain.

Hemo,

I don't think its a regards to the absorption/bio availability of Chrysin.

I think its more of a regards of the fact that Chrysin just doesn't inhibit the aromatase enzyme.

The only plant extract/herb/OTC thing that I have seen potentiate some sort of AI activity that is possibly worth seeking is resveratrol, and possibly zinc.

Resveratrol does this by a few mechanisms. First, it exerts effects on calorie restriction genes, one of which will reduce the aromatase enzyme.

Second, it has mild SERM like properties.

However, dosing/absorption are issues. Note that it probably not strong enough for most.

But it may be a nice supplement for those looking for a maintenance supp to help maintain healthy estrogen levels.

[JanSz]

Hemo,

I don't think its a regards to the absorption/bio availability of Chrysin.

I think its more of a regards of the fact that Chrysin just doesn't inhibit the aromatase enzyme.

The only plant extract/herb/OTC thing that I have seen potentiate some sort of AI activity that is possibly worth seeking is resveratrol, and possibly zinc.

Resveratrol does this by a few mechanisms. First, it exerts effects on calorie restriction genes, one of which will reduce the aromatase enzyme.

Second, it has mild SERM like properties.

However, dosing/absorption are issues. Note that it probably not strong enough for most.

But it may be a nice supplement for those looking for a maintenance supp to help maintain healthy estrogen levels.

Pumpkin seed oil.

AI & 5aR inhibitor.

At least that is what lef.org claims


http://musclechatroom.com/forum/showthread.php?t=12696

http://www.lef.org/magazine/mag2008/nov2008_Pumpkin-Seed-Relieves-Overactive-Bladder-Urinary-Incontinence_01.htm

''' and pumpkin seed extract was effective in inhibiting 5-alpha reductase activity by 50%.''''

""water-soluble pumpkin seed extract was shown to reduce aromatase levels by 50%""

[Wise Guy]

Pumpkin seed oil.

AI & 5aR inhibitor.

At least that is what lef.org claims


http://musclechatroom.com/forum/showthread.php?t=12696

http://www.lef.org/magazine/mag2008/nov2008_Pumpkin-Seed-Relieves-Overactive-Bladder-Urinary-Incontinence_01.htm

''' and pumpkin seed extract was effective in inhibiting 5-alpha reductase activity by 50%.''''

""water-soluble pumpkin seed extract was shown to reduce aromatase levels by 50%""

If such was the case, arimidex would be out of business.

I'm simply not buying it.

[Hemochromatosis]

Hemo,

I don't think its a regards to the absorption/bio availability of Chrysin.

I think its more of a regards of the fact that Chrysin just doesn't inhibit the aromatase enzyme.

The only plant extract/herb/OTC thing that I have seen potentiate some sort of AI activity that is possibly worth seeking is resveratrol, and possibly zinc.

Resveratrol does this by a few mechanisms. First, it exerts effects on calorie restriction genes, one of which will reduce the aromatase enzyme.

Second, it has mild SERM like properties.

However, dosing/absorption are issues. Note that it probably not strong enough for most.

But it may be a nice supplement for those looking for a maintenance supp to help maintain healthy estrogen levels.

Yes, I have heard of Resveratrol as a potential AI. The problem is that Resveratrol is a blood thinner on par with policosanol. This is a problem with someone on coumadin. I loaded policosanol on top of coumadin once and ruptured my left eye and made my sweet meat look like Loraine Bobbet had a field day on it! I would venture to guess that Resveratrol's thinning property act on platelets and not fibrin (subject to confirmation).

However, I have been working with an extractor to separate the phytocons of white button mushroom from the rest of the shroom properties, specifically the purines. The purines create uric acid spikes and concentrations. Before I test I will need access to a GC/MS and have a differential CBC taken concurrently.

[Hemochromatosis]

I guess I am too old and jaded to trust anything I can 't find empirical data, although I have tested on myself a number of times. I do not even trust empirical data half the time when I find big pharm behind every corner.

I wish there was a site that had people posting labs and self trial data, realizing it can be as bogus as anything. Pain is a great motivator and I notice the advice I have obtained from certain boards where people were more concerned with survival than appearance or competition that those venues seem to realize a great level of research, diligence and realism.

[chilln]

Just realized we are not suppose to post any links to products. I hope this remains compliant for I have no other interest other than usage and efficacy.

Has anyone tried AE-3 (Chrysin with Perine. Perine to potentiate and make bioavailable the Chrysin)

I tried Arimidex and on a low dose had a reaction. I looked into IC3, but am not convinced. My E2 is out of control and is at about a 10:1 to total T.

Please help.


There is a sinister problem with Chrysin which is debilitating for males. This debilitation outweighs the positive effect of Chrysin's aromatase inhibition.

Chrysin is far less than optimum for male health because it also blocks the action of a high percentage of human 17β-hydroxysteroid dehydrogenase type 5.

17β-hydroxysteroid dehydrogenase type 5 is the enzyme responsible for the following conversions:
a) androstenedione <---> testosterone
b) androstenediol <--> androsterone

Since we males need these conversions to take place at their uninhibited levels, therefore we don't want chrysin in our systems.

reference:
"Phytoestrogens inhibit human 17β-hydroxysteroid dehydrogenase type 5"

http://gbic.biol.rug.nl/~rbreitling/publications/HSD5Inhibition.pdf

You're better off discussing with your medical professional adviser to use low dose arimidex.

You can purchase arimidex in dosages as low as 0.05mg per cap, from a compounding pharmacy, per this discussion here:

http://musclechatroom.com/forum/showpost.php?p=59066&postcount=31

.